Protein name:
Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1;NFATc1) ;
Alternative:
NFAT transcription complex cytosolic component (NF-ATc;NFATc) ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers.
Function:
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells.
Subcellular Location:
Cytoplasm
Nucleus
Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
Protein Attributes:
50:
MTGLEEDQEF | DFDFLFEFNQ | SDEGAVAAPA | EHYGYAAPGL | GAGLPLSAAH |
100:
PSLPAPCHDL | QSSAAGVSAV | GYGGTVDSGP | SGYFLSSGGI | RPNGAPALES |
150:
PRIEITSYLG | LHHNSSQFLH | EVDVEDVLPK | RSPSTATLNL | PSLEAYRDPS |
200:
CLSPASSLSS | RSCNSEASSY | ESSFSYPYAS | PQTSPWQSPC | VSPKTTDPEE |
250:
GFARGLGACG | LLGSPRHSPS | TSPRTSVTEE | SWLGARTSRP | SSPCNKRKYG |
300:
LNGRQLSCSP | HPSPTPSPQG | SPRVSVTDDT | WLGNTTQYTS | SAIVAAINAL |
350:
STDSSLDLGD | GVPVKARKTT | LDHSPAVALK | VEPAGEDLGT | TPPTPDFQPE |
400:
EFAAFQHIRK | GAFCDQYLSV | PQHPYPWARP | RSPASYTSPS | LPALDWQLPS |
450:
HSGPYELRIE | VQPKSHHRAH | YETEGSRGAV | KASAGGHPSV | QLHGYVESEP |
500:
LTLQLFIGTA | DDRLLRPHAF | YQVHRITGKT | VSTASHEAVV | CSTKVLEIPL |
550:
LPENNMRATI | DCAGILKLRN | SDIELRKGET | DIGRKNTRVR | LVFRVHIPQP |
600:
NGRTLSLQVA | SNPIECSQRS | AQELPLVEKQ | SAASGPVLGG | KRMVLSGHNF |
650:
LQDSKVIFVE | KAPDGHHIWE | MEAKTEGDLC | KPNSLVVEIP | PFRNQRITSP |
700:
VQVNFYVCNG | KRKRSQYQHF | TYLPANVPII | KTEPSDDYEP | ALTCGPMSQG |
750:
LSPLPKPCYG | QPLALPPDPG | ACLMPGFPPR | PQGSASPELH | DLSCAPYGSA |
800:
TAGPGHSPLG | LPRPVGGVLA | SQEAPRPSGV | PPGPPQPPPP | TLLQPQVSPT |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Pig
ELISA Kit for Bovine NF-ATc1
ELISA Kit for Bovine NF-ATc1
ELISA Kit for Bovine NF-ATc1
ELISA Kit for Bovine NF-ATc1
CLIA Kit for Bovine NF-ATc1
CLIA Kit for Bovine NF-ATc1
CLIA Kit for Bovine NF-ATc1
CLIA Kit for Bovine NF-ATc1
Polyclonal Antibody for Bovine NF-ATc1
Polyclonal Antibody for Bovine NF-ATc1
Polyclonal Antibody for Bovine NF-ATc1
Polyclonal Antibody for Bovine NF-ATc1
Monoclonal Antibody for Bovine NF-ATc1
Monoclonal Antibody for Bovine NF-ATc1
Monoclonal Antibody for Bovine NF-ATc1
Monoclonal Antibody for Bovine NF-ATc1
Protein for Bovine NF-ATc1
Protein for Bovine NF-ATc1
Protein for Bovine NF-ATc1
Protein for Bovine NF-ATc1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Hereford .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 415-430; 432-441; 518-534; 536-545; 554-560 AND 612-615
tissue :
Thymus .